Cancer is the leading cause of death by disease in children and adolescents in the US

Brain and Central Nervous System tumors are the most common cancer in children 0-14 years in the US

There are more than 140 different types of brain tumors, many with their own multitude of subtypes

Childhood cancer survivors are at significant risk for secondary cancers later in life

More than 28,000 children (0-19 years of age) are estimated to be living with a brain tumor in the US

About 4,600 children and teenagers are diagnosed with a primary brain or central nervous system tumor every year.  That's 13 new cases a day

Between 1998 and 2014, there were 78 investigational brain tumor drugs that entered the clinical trial evaluation process-75 failed.  That is a 25:1 failure ratio in developing new brain tumor treatments over the past 2 decades

Brain tumors affect all races, ages, gender, and ethnicities

All types of childhood cancer combined receive less than 4% of the US Federal funding for cancer research

More than 40,000 children undergo treatment for cancer each year

Childhood cancer does not discriminate, sparing no ethnic group, socioeconomic class or geographic region

Brain tumors are often located in the control center for thought, memory, sensation, emotion, vision and movement, and therefore, their effect can be particularly devastating

The overall mortality rate of pediatric cancer has decreased in past 20 years, but deaths from brain and spinal cord tumors have increased from 18% to 30%

Among the chemotherapy side effects are hair loss, skin problems, nausea, vomiting, diarrhea, constipation, changes in taste, fatigue, mouth sores, seizures, hearing loss, kidney and liver problems, and reduction of platelets, red cells, or white cells in the blood.  Some are temporary others maybe permanent

Brain tumors have the highest per-patient initial cost of care for any cancer group

The causes of most pediatric cancer remain a mystery and cannot be prevented

Many brain tumor survivors require physical, cognitive and rehabilitation services to allow them to return to tasks of everyday life

Pediatric brain tumors are different from those in adults and are often treated differently

Pediatric brain tumors aren't like those in adults.  Children's brain tumors require specific research and different treatments

Despite the amount of brain tumors, and their devastating prognosis, there have only been 4 FDA approved drugs-and 1 device-to treat brain tumors in the past 30 years

The terms "benign" and "malignant" as usually applied to tumors are not as useful when describing brain tumors, because the brain and skull comprise a "box" of a fixed size, even "benign" or slow-growing tumors can cause serious problems or eventual death if they develop in an area where complete surgical removal is not possible

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